Recent research publications
1. Howes, N., Greenhalf, W., and Raraty, G. T. R. Medical Treatment of Chronic Pancreatitis: Antioxidants. In: H.-G. Beger, M. Buchler, R. Kozarek, M. Lerch, J. Neoptolemos, A. Warshaw, D. Whitcomb, and K. Shiratori (eds.), The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, pp. 523-525. Oxford: Blackwell, 2008.
2. Greenhalf, W., Vitone, L. J., and Neoptolemos, J. Familial Pancreatic Cancer. In: H.-G. Beger, M. Buchler, R. Kozarek, M. Lerch, J. Neoptolemos, A. Warshaw, D. Whitcomb, and K. Shiratori (eds.), The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, pp. 591-600. Oxford: Blackwell, 2008.
3. Greenhalf, W., Malats, N., Nilsson, M., Bartsch, D., and Neoptolemos, J. International Registries of Families at High Risk of Pancreatic Cancer. Pancreatology, 8: 558-565, 2008.
4. Carlson, C., Greenhalf, W., and Brentnall, T. A. Screening of Hereditary Pancreatic Cancer Families. In: H.-G. Beger, M. Buchler, R. Kozarek, M. Lerch, J. Neoptolemos, A. Warshaw, D. Whitcomb, and K. Shiratori (eds.), The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery: Blackwell, 2008.
5. Slater, E., Amrillaeva, V., Fendrich, V., Bartsch, D., Earl, J., Vitone, L. J., Neoptolemos, J. P., and Greenhalf, W. Palladin mutation causes familial pancreatic cancer: absence in European families. PLoS Med, 4: e164, 2007.
6. Grocock, C. J., Vitone, L. J., Harcus, M. J., Neoptolemos, J. P., Raraty, M. G., and Greenhalf, W. Familial pancreatic cancer: a review and latest advances. Adv Med Sci, 52: 37-49, 2007.
7. Vitone, L. J., Greenhalf, W., McFaul, C. D., Ghaneh, P., and Neoptolemos, J. P. The inherited genetics of pancreatic cancer and prospects for secondary screening. Best Pract Res Clin Gastroenterol, 20: 253-83, 2006.
8. Vitone, L. J., Greenhalf, W., Howes, N. R., Raraty, M. G., and Neoptolemos, J. P. Trypsinogen mutations in pancreatic disorders. Endocrinol Metab Clin North Am, 35: 271-87, viii, 2006.
9. McFaul, C., Greenhalf, W., Earl, J., Howes, N., Neoptolemos, J., Kress, R., Sina-Frey, M., Rieder, H., Hahn, S. A., and Bartsch, D. Anticipation in familial pancreatic cancer. Gut, 55: 252-258, 2006.
10. Latchford, A., Greenhalf, W., Vitone, L. J., Neoptolemos, J. P., Lancaster, G. A., and Phillips, R. K. Peutz-Jeghers syndrome and screening for pancreatic cancer. Br J Surg, 93: 1446-55, 2006.
11. Greenhalf, W., and Neoptolemos, J. P. Increasing survival rates of patients with pancreatic cancer by earlier identification. Nat Clin Pract Oncol, 3: 346-7, 2006.
12. Greenhalf, W. An unfavourable prognosis for pancreatic cancer indicates fields of opportunity. Gut, 55: 1533-5, 2006.
13. Earl, J., Yan, L., Vitone, L. J., Risk, J., Kemp, S. J., McFaul, C., Neoptolemos, J. P., Greenhalf, W., Kress, R., Sina-Frey, M., Hahn, S. A., Rieder, H., and Bartsch, D. K. Evaluation of the 4q32-34 locus in European familial pancreatic cancer. Cancer Epidemiol Biomarkers Prev, 15: 1948-55, 2006.
14. Yan, L., McFaul, C., Howes, N., Leslie, J., Lancaster, G., Wong, T., Threadgold, J., Evans, J., Gilmore, I., Smart, H., Lombard, M., Neoptolemos, J., and Greenhalf, W. Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups. Gastroenterology, 128: 2124-30, 2005.
15. Vitone, L. J., Greenhalf, W., Howes, N. R., and Neoptolemos, J. P. Hereditary pancreatitis and secondary screening for early pancreatic cancer. Rocz Akad Med Bialymst, 50: 73-84, 2005.
16. Vitone, L., Greenhalf, W., and Neoptolemos, J. P. Secondary Screening for Pancreatic Cancer in High Risk Groups. In: T. M. Gress, J. P. Neoptolemos, N. R. Lemoine, and F. X. Real (eds.), Exocrine Pancreas Cancer: EPC-RC, pp. 44-61. Hannover: Felsenstein CCCP, 2005.
17. Howes, N., Greenhalf, W., Stocken, D. D., and Neoptolemos, J. P. Cationic trypsinogen mutations and pancreatitis. Clin Lab Med, 25: 39-59, 2005.
18. Hahn, S. A., Vitone, L., Greenhalf, W., Bartsch, D., and Neoptolemos, J. P. Familial Pancreatic Cancer Syndromes. In: T. M. Gress, J. P. Neoptolemos, N. R. Lemoine, and F. X. Real (eds.), Exocrine Pancreas Cancer: EPC-RC, pp. 44-61. Hannover: Felsenstein CCCP, 2005.
19. Greenhalf, W., Vitone, L., and Neoptolemos, J. P. Molecular Diagnosis of Pancreatic Cancer in Pancreatic Juice. In: T. M. Gress, J. P. Neoptolemos, N. R. Lemoine, and F. X. Real (eds.), Exocrine Pancreas Cancer: EPC-RC, pp. 404-425. Hannover: Felsenstein CCCP, 2005.
20. Cohn, J. A., Neoptolemos, J. P., Feng, J., Yan, J., Jiang, Z., Greenhalf, W., McFaul, C., Mountford, R., and Sommer, S. S. Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. Hum Mutat, 26: 303-7, 2005.
21. Bartsch, D. K., Fendrich, V., Slater, E. P., Sina-Frey, M., Rieder, H., Greenhalf, W., Chaloupka, B., Hahn, S. A., Neoptolemos, J. P., and Kress, R. RNASEL germline variants are associated with pancreatic cancer. Int J Cancer, 117: 718-22, 2005.
22. Howes, N., Lerch, M. M., Greenhalf, W., Stocken, D. D., Ellis, I., Simon, P., Truninger, K., Ammann, R., Cavallini, G., Charnley, R. M., Uomo, G., Delhaye, M., Spicak, J., Drumm, B., Jansen, J., Mountford, R., Whitcomb, D. C., and Neoptolemos, J. P. Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin Gastroenterol Hepatol, 2: 252-61, 2004.
23. Howes, N., Greenhalf, W., Stocken, D. D., and Neoptolemos, J. P. Cationic trypsinogen mutations and pancreatitis. Gastroenterol Clin North Am, 33: 767-87, 2004.
24. Grutzmann, R., McFaul, C., Bartsch, D. K., Sina-Frey, M., Rieder, H., Koch, R., McCarthy, E., Greenhalf, W., Neoptolemos, J. P., Saeger, H. D., and Pilarsky, C. No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma. Cancer Lett, 214: 63-8, 2004.
25. Yan, J., Cohn, J., Neoptolemos, J., Feng, J., Jiang, Z., Greenhalf, W., Ellis, I., and Sommer, S. Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. American Journal of Human Genetics, 73: 1252, 2003.
26. Hahn, S. A., Greenhalf, B., Ellis, I., Sina-Frey, M., Rieder, H., Korte, B., Gerdes, B., Kress, R., Ziegler, A., Raeburn, J. A., Campra, D., Grutzmann, R., Rehder, H., Rothmund, M., Schmiegel, W., Neoptolemos, J. P., and Bartsch, D. K. BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst, 95: 214-21, 2003.
27. Poll, A., Howes, N., Greenhalf, W., Campra, D., Delhaye, M., Elmslie, F., Olah, A., Uomo, G., Neoptolemos, J. P., and Ellis, I. Early age of onset in pancreatic cancer families on the EUROPAC collaborative register. Abstract. Pancreatology, 2002.
28. McFaul, C., Greenhalf, W., Howes, N., Hont, C., Uomo, G., Pasquale, C., Neoptolemos, J., and Ellis, I. Anticipation and earlier male age of onset in familial pancreatic cancer (FPC) patients on the European registry of hereditary pancreatitis and familial pancreatic cancer (EUROPAC). Pancreas, 45: 440, 2002.
29. Threadgold, J., Greenhalf, W., Ellis, I., Howes, N., Lerch, M. M., Simon, P., Jansen, J., Charnley, R., Laugier, R., Frulloni, L., Olah, A., Delhaye, M., Ihse, I., Schaffalitzky de Muckadell, O. B., Andren-Sandberg, A., Imrie, C. W., Martinek, J., Gress, T. M., Mountford, R., Whitcomb, D., and Neoptolemos, J. P. The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. Gut, 50: 675-81, 2002.
30. Wong, T., Howes, N., Threadgold, J., Smart, H. L., Lombard, M. G., Gilmore, I., Sutton, R., Greenhalf, W., Ellis, I., and Neoptolemos, J. P. Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients. Pancreatology, 1: 486-509, 2001.
31. Wong, T., Howes, N., Lombard, M., Smart, H., Gilmore, I., Sutton, R., Campbell, F., Kang, Y., Ellis, I., Greenhalf, W., and Neoptolemos, J. Real-time KRAS mutational analysis in the diagnosis of early pancreatic ductal adenocarcinoma. BRITISH JOURNAL OF CANCER, 85: 55-55, 2001.
32. Magee, C. J., Greenhalf, W., Howes, N., Ghaneh, P., and Neoptolemos, J. P. Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications. Surg Oncol, 10: 1-23., 2001.
33. Howes, N., Greenhalf, W., Rutherford, S., O'Donnell, M., Mountford, R., Ellis, I., Whitcomb, D., Imrie, C., Drumm, B., and Neoptolemos, J. P. A new polymorphism for the RI22H mutation in hereditary pancreatitis. Gut, 48: 247-250., 2001.
34. Wong, T., Greenhalf, W., Lombard, M., Smart, H., Gilmore, I., Sutton, R., Fox, J., and Neoptolemos, J. K-ras mutations in the absence of malignancy: Implications for diagnostic and prognostic use. Digestion, 61: 308, 2000.
35. Threadgold, J., Howes, N., Neoptolemos, J. P., and Greenhalf, W. Detection of p53 mutations in pancreatic juice of patients at high risk of PDAC. Proceedings of the American Association for Cancer Research, 41: 1425 (Abstract), 2000.
36. Howes, N., Wong, T., Greenhalf, W., Lerch, M. M., Deviere, J., O'Donnell, M., Ellis, I., Mountford, R., Neoptolemos, J., and For the EUROPAC Consortium. Pancreatic Cancer Risk In Hereditary Pancreatitis In Europe. Digestion, 61: 300 (abstract), 2000.
37. Howes, N., Greenhalf, W., and Neoptolemos, J. Screening for early pancreatic ductal adenocarcinoma in hereditary pancreatitis. Med Clin North Am, 84: 719-38, 2000.
